Pharmacology In Drug Discovery And Development ~upd~ Link

Beta-blockers (like propranolol) are antagonists at beta-adrenergic receptors. Their PD profile—specifically, their ability to block adrenaline without activating the receptor—lowers heart rate and blood pressure. A molecule with slightly different PD properties (partial agonism) would fail as a beta-blocker.

By studying —how a person's genetic makeup affects their response to drugs—pharmacologists can now predict who will benefit from a drug and who might suffer toxic side effects. pharmacology in drug discovery and development

Drug discovery without pharmacology is alchemy—full of hope but devoid of predictability. The pharmacologist’s mantra echoes through every phase of development: pharmacology in drug discovery and development