RE6 relies on older Visual C++ runtimes. Corruption here can manifest as file access errors.

Navigate to %USERPROFILE%\Documents\CAPCOM\RESIDENT EVIL 6\ . Open config.ini in a text editor like Notepad.

If specific error mentions a file (rare), check its presence:

Go to the tab and click Verify integrity of game files .

This error usually indicates that the game cannot locate its configuration files or executable because of permission issues or because Windows Defender has quarantined a critical file.