To ensure that your save game is properly backed up, consider the following:

In Sequence 4, after completing the mission “The Man They Called Connor” (where you first get your robes and tomahawk), the game auto-saves before “Journey to the New World.” But a faulty trigger in the remaster sometimes fails to update the save metadata. The result: the game thinks you’re still in Sequence 3, or it loads you into a blank, snow-covered Boston with no NPCs.

C:\Program Files (x86)\Ubisoft\Ubisoft Game Launcher\savegame\ \5183