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: The framework of Replacement, Reduction, and Refinement continues to evolve, ensuring that animals used in teaching or research are treated with the highest ethical standards of humane science. Key Figures and Resources All animals need choice and control

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Chronic pain, especially from arthritis, is a leading cause of irritability in senior pets. When the pain is treated, the "aggression" often vanishes. 2. Behavioral Pharmacology : The framework of Replacement