The game was built for single-core CPUs. To prevent crashes, you must set your CPU affinity to a single core.

Running a 20-year-old game on modern hardware requires some minor "under-the-hood" tweaks.

Version 1.1.641 is the final official build of SimCity 4: Rush Hour (or SimCity 4 Deluxe). It represents the game in its most stable, feature-complete state. Why the Version Number Matters

Because 1.1.641 is a legacy application, further tweaks are often needed for modern hardware: Resolution - SimCity | Fandom